Build unique per-chromosome reference k-mer lists

This reproduces the first filtering stage of the legacy NIPTmer workflow: remove globally non-unique k-mers from chromosome-specific lists.

Usage

niptmer_build_reference_lists(
  fasta_files,
  k = 25,
  out_dir = ".",
  threads = 1,
  genome_build = NA_character_
)

Arguments

fasta_files

Character vector of chromosome FASTA paths.

k

K-mer size.

out_dir

Output directory for generated lists.

threads

Number of threads passed to glistmaker.

genome_build

Optional genome build label stored in the returned panel.

Value

A niptmer_ref_panel object.